Publication: Golgi apparatus localization of ZNT7 in the mouse cerebellum
Authors
Gao, Hui-Ling ; Feng, Wan-Yu ; Li, Xiao-Ling ; Xu, He ; Huang, Liping ; Wang, Zhan-You
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Publisher
Murcia : F. Hernández
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Description
Abstract
We have recently reported that four members
of the zinc transporter (ZNT) family, ZNT1, ZNT3,
ZNT4, and ZNT6, are abundantly expressed in the
mouse cerebellum. In the present study, we reported that
ZNT7 was present throughout the cerebellar cortex.
ZNT7 immunoreactivity was predominately present in
the somas and primary dendrites of the Purkinje cells.
ZNT7 was also present in the Bergmann glial cell bodies
as well as their radial processes, which extended into the
molecular cell layer. Confocal immunofluorescence
results demonstrated that the expression of ZNT7
overlapped with that of TGN38 in the somas of the
Purkinje cells and granule cells. Immuno-electron
microscopic study showed that ZNT7 was localized to
the membrane of the Golgi apparatus in the somas of the
Purkinje cells, Bergmann glial cells, and granule cells.
Western blot analysis demonstrated that a considerable
amount of ZNT7 was expressed in the cerebellum. These
findings suggest a significant role of ZNT7 in zinc
homeostasis in the mouse cerebellum.
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