Publication: Insulin receptors and signal transduction proteins in the hypothalamo-hypophyseal system, a review on morphological...
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Date
1998
Authors
Unger, J.W. ; Betz, M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Receptors for insulin are widely distributed
in the brain and pituitary. The current hypothesis on
receptor function in these regions points to a role of
insulin as a mediator in the communication of the
peripheral endocrine system with the brain via various
steps of the neuroendocrine axis. Recent data
demonstrate that receptor-positive neurons in the brain,
i.e. in the hypothalamus, and secretory cells in the
anterior pituitary gland possess specific proteins that are
thought to be involved in key steps of post receptor
signal transduction, in particular insulin receptor
substrate-1 and phosphatidylinositol 3'-kinase (PI3k).
PI3k is a critical enzyme of the intracellular signaling
pathway that is activated by a number of receptor
tyrosine kinases, including receptors for insulin and IGF-
1. This information further completes the framework
indicating in vivo activity of insulin receptors in central
neuroendocrine cells and their involvement in one
branch of several physiological mechanisms that control
body metabolism and nutritional behaviour.
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