Publication: Tumor-associated fibroblasts (Part II): functional impact on tumor tissue
Authors
Kunz-Schughart, L.A. ; Knuechel, R.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The article focuses on the functional impact
of tumor-associated fibroblasts (TAF) on its surrounding
cells. It intends to cover the recent knowledge on TAF,
the phenotype, and expression profile of which have
been described in the first part of the rev i ew series
( Kunz-Schughart and Knuechel, 2002). The present
r ev i ew is subdivided into two main chapters: (1)
functional impact of TAF on tumor cells and (2)
fibroblast-host cell interactions in tumor tissue. In the
first paragraph of chapter (1) about the role of fibroblasts
in tumor cell growth and differentiation it is reve a l e d ,
h ow strongly cellular interaction is dependent on
fibroblast and tumor cell type as well as the spatial ratio
between the cells. The variation of cellular behav i o r
depending on quantity of molecules holds also true for
the group of ECM molecules, e.g. the balance between
MMPs and TIMPs, which provide an interesting
therapeutic target in tumor tissue. This is one of the
topics addressed in the second paragraph which focuses
on tumor cell dissemination. Chapter (2) addresses the
relation of TAF to other intra- or peritumoral host cells.
The hypoxia-related angiogenesis induction of
fibroblasts via growth factor secretion (e.g. VEGF) is
considered as important as the immune modulatory
properties of fibroblasts on immune cells, such as m o n o cytes/macrophages. These cellular properties can
be tested under controlled conditions in threedimensional
heterologous cultures of human cells,
p r oviding the chance for systematic modification to
assess therapeutic effects in an in vivo like environment.
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