Publication: Integrin-mediated signal transduction pathways
Authors
Cary,L.A. ; Han, D.C. ; Guan, J.L.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Integrins serve as adhesion receptors for
extracellular matrix proteins and also transduce
biochemical signals into the cell. They regulate a variety
of cellular functions, including spreading, migration,
proliferation and apoptosis. Many signaling pathways
downstream of integrins have been identified and
characterized and are discussed here. In particular,
integrins regulate many protein tyrosine kinases and
phosphatases, such as FAK and Src, to coordinate many
of the cell processes mentioned above. The regulation of
MAP kinases by integrins is important for cell growth or
other functions, and the putative roles of Ras and FAK in
these pathways are discussed. Phosphatidylinositol lipids
and their modifying enzymes, particularly PI 3-kinase,
are strongly implicated as mediators of integrinregulated
cytoskeletal changes and cell migration.
Similarly, actin cytoskeleton regulation by the Rho
family of GTPases is coordinated with integrin signaling
to regulate cell spreading and migration, although the
exact relationship between these pathways is not clear.
Finally, intracellular pH and calcium fluxes by integrins
are suggested to affect a variety of cellular proteins and
functions.
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