Publication: Density and migration of mast cells in lip squamous cell carcinoma and actinic cheilitis
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Date
2009
Authors
Lago Costa, Nádia ; Ferreira Oton-Leite1, Angélica ; Peixoto Cheim-Júnior, Adonai ; Gonçalves Alencar, Rita de Cássia ; Jabur Bitta, Glória Oton ; Aparecida Silva, Tarcília ; Carvalho Batista, Aline
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Mast cells (MCs) display a diversity of roles
that may contribute to the stromal microenvironment
alterations during tumor progression. The aim of this
study was to investigate MC populations expressing
tryptase and c-kit in lip squamous cell carcinoma (lip
SCC) (n=37), actinic cheilitis (AC) (n=15) and normal
lip mucosa (control) (n=6), as well as their relationship
with microscopic parameters (collagen degeneration,
elastin changes, angiogenesis and proliferative index).
Tryptase, c-kit, CD31 and Ki-67 expressions were
analyzed by means of immunohistochemistry and
collagen and elastic fibers were visualized with
Picrosirus and Verhoeff’s stain, respectively. The
numbers of tryptase+ MC were significantly higher in lip
SCC when compared with control (P=0.01), while a
similar density of these cells was observed in AC and lip
SCC (P=0.09). The density of c-kit+ MC was similar in
all groups examined (P=0.65). MC migration (ckit+/Tryptase+ relationship) was 69% in lip SCC, 60%
in AC and 100% in control. The number of CD31+
blood vessels was significantly higher in the lip SCC
when compared with control and AC (P<0.01). The
increase of MCs and angiogenesis in lip SCC may
reflect an important modification in the
tumor microenvironment during squamous photocarcinogenesis.
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