Publication: Hepatocellular carcinoma in non-alcoholic fatty liver disease (NAFLD) - pathological evidence for a predominance of steatohepatitic inflammatory non-proliferative subtype
Authors
Campos de, Priscila B. ; Oliveira, Claudia P. ; Stefano, José T. ; Martins-Filho, Sebastião N. ; Chagas, Aline L. ; Herman, Paulo ; Albuquerque de, Luiz C. ; Alvares-da-Silva, Mário R. ; Longatto-Filho, Adhemar ; Carrilho, Flair J. ; Alves, Venancio A.F.
item.page.secondaryauthor
item.page.director
Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
publication.page.editor
publication.page.department
DOI
https://doi.org/10.14670/HH-18-194
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Objectives. This study evaluated clinical and
pathological aspects of patients with hepatocellular
carcinoma (HCC) secondary to non-alcoholic fatty liver
disease (NAFLD) and related these factors to
immunohistochemical markers representative of the
proliferative class.
Methods. We evaluated 35 HCC nodules from 21
patients diagnosed with NAFLD undergoing liver
resection (n=12) or liver transplantation (n=8) or both
(n=1). Demographic, clinical and biochemical data were
compared to histological features and to immunohisto-
chemical reactivity for K19 and Ki-67.
Results. Cirrhosis was present in 58% of patients.
Ages ranged from 50 to 77 years. Sixteen patients (76%)
were male and had type 2 diabetes mellitus, 81% had
arterial hypertension, and 90% had BMI above 25
kg/m 2. Alpha-fetoprotein levels were normal in 62% of
patients. Twenty-five (70%) nodules were diagnosed as
“steatohepatitic HCC”. Only 32% of the nodules
presented high levels of Ki-67 (>10%) and/or K19
(>5%), although 63% were poorly differentiated
(G.3/G.4) according to Edmondson & Steiner grading
system. K19 positivity (>5%) was associated with higher
degree of intratumoral inflammation (G.2/G.3), and with
fibrosis, both at the center of the tumor and at the tumor
front, whereas Ki-67 positivity (>10%) was associated
with ballooning of neoplastic cells and occurred in more
than 70% in non-cirrhotic patients.
Conclusion. NAFLD-related HCC was found in non-
cirrhotic patients in 42% of cases, alpha-fetoprotein level
was normal in 63% and "steatohepatitic HCC" was the
predominant histological type. Immunoexpression of K19
and/or Ki-67 occurred in 32% of the nodules and were
associated with intratumoral inflammation and ballooning,
suggesting that HCC in MtS may be preferentially “an
inflammatory, non-proliferative subtype of HCC”
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Este ítem está sujeto a una licencia Creative Commons. CC BY 4.0