Publication: Advances in pediatric rhabdomyosarcoma characterization and disease model development
Authors
O’ Brien, Dennis ; Jacob, Aishwarya G. ; Qualman, Stephen J. ; Chandler, Dawn S.
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Rhabdomyosarcoma (RMS), a form of soft tissue sarcoma, is one of the most common pediatric malignancies. A complex disease with at least three
different subtypes, it is characterized by perturbations in
a number of signaling pathways and genetic
abnormalities. Extensive clinical studies have helped
classify these tumors into high and low risk groups to
facilitate different treatment regimens. Research into the
etiology of the disease has helped uncover numerous
potential therapeutic intervention points which can be
tested on various animal models of RMS; both
genetically modified models and tumor Xenograft
models. Taken together, there has been a marked
increase in the survival rate of RMS patients but the
highly invasive, metastatic forms of the disease continue
to baffle researchers. This review aims to highlight and
summarize some of the most important developments in
characterization and
in vivo
model generation for RMS
research, in the last few decades.
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Citation
Histology and histopathology, Vol. 27, nº 1 (2012)
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