Publication: Catenins and their associated proteins in colorectal cancer
Authors
Tucker, E.L. ; Pignatelli, M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Colorectal cancer is the second most
common cause of cancer mortality in the western world.
Colorectal cancer has been well studied, and the genetic
steps involved in the adenoma to carcinoma sequence
have been well elucidated. The first genetic alteration,
found in 85% of adenomas, are mutations in the
adenomatous polyposis coli (MC) gene. However, the
consequences of this and the exact function of APC in
the colon is not fully understood. It has been suggested
that APC could function through its regulation of Bcatenin,
an ubiquitous cytoskeletal protein with multiple
binding specificities resulting in diverse functions
including cell growth, adhesion, and migration. Any
change in these associations may play a role in
colorectal cancer development and progression.
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