Publication: Ultrastructural morphology of equine adipose-derived mesenchymal stem cells
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Date
2010
Authors
Pascucci, Luisa ; Mercati, Francesca ; Marini, Carla ; Ceccarelli, Piero ; Dall’Aglio, C. ; Pedini, Vera ; Gargiulo, Anna María
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Publisher
Murcia : F. Hernández
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Description
Abstract
Mesenchymal stem cells are a virtually
ubiquitous population of adult stem cells, able to
differentiate into various tissue lineages. As they are
multipotent and easy to grow in culture, they are at
present considered very attractive candidates for tissue
repair and gene therapy. With the exception of a few
reports, mesenchymal stem cell morphology has been
widely disregarded in the past years. In this paper we
discuss the establishment of mesenchymal stem cell
cultures from equine adipose tissue and describe their
fine structure by transmission electron microscopy. The
cultured cells revealed a fibroblastoid appearance and
were characterized by an eccentric nucleus with multiple
nucleoli, dense cytoplasm rich in ribosomes, a rough
endoplasmic reticulum with dilated cisternae, elongated
mitochondria and heterogeneous vacuolar inclusions. In
addition, they were often interconnected by adhesion
structures located on the cell body and on cytoplasmic
processes contacting other cells. The features observed
are evocative of an undifferentiated cellular phenotype
and of an intense synthetic and metabolic activity.
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