Publication: Localization of sex steroid receptors in human skin
Authors
Pelletier, G. ; Ren, L.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Sex steroid hormones are involved in
regulation of skin development and functions as well as
in some skin pathological events. To determine the sites
of action of estrogens, androgens and progestins, studies
have been performed during the recent years to
accurately localize receptors for each steroid hormone in
human skin. Androgen receptors (AR) have been
localized in most keratinocytes in epidermis. In the
dermis, AR was detected in about 10% of fibroblasts. In
sebaceous glands, AR was observed in both basal cells
and sebocytes. In hair follicles, AR expression was
restricted to dermal papillar cells. In eccrine sweat
glands, only few secretory cells were observed to
express AR. Estrogen receptor (ER) a was poorly
expressing, being restricted to sebocytes. In contrast,
ERß was found to be highly expressed in the epidermis,
sebaceous glands (basal cells and sebocytes) and eccrine
sweat glands. In the hair follicle, ERß is widely
expressed with strong nuclear staining in dermal papilla
cells, inner sheath cells, matrix cells and outer sheath
cells including the buldge region. Progesterone receptors
(PR) staining was found in nuclei of some keratinocytes
and in nuclei of basal cells and sebocytes in sebaceous
glands. PR nuclear staining was also observed in dermal
papilla cells of hair follicles and in eccrine sweat glands.
This information on the differential localization of sex
steroid receptors in human skin should be of great help
for future investigation on the specific role of each
steroid on skin and its appendages.
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