Publication: Emergent roles for intercellular adhesion molecule-1 in the restructuring of the blood-testis barrier during spermatogenesis in the mammal
Authors
Mruk, Dolores D.
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Publisher
Universidad de Murcia. Departamento de BiologĂa Celular e HistologĂa
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DOI
10.14670/HH-11-672
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info:eu-repo/semantics/article
Description
Abstract
Mammalian spermatogenesis is comprised of
a series of molecular, cellular, and morphological events
that underscore the movement of developing germ cells
across the blood-testis barrier. These events involve the
restructuring of tight junctions, basal ectoplasmic
specializations, gap junctions, and desmosomes, which
constitute blood-testis barrier function. Previous studies
show that preleptotene/leptotene spermatocytes traverse
the blood-testis barrier while transiently trapped within
an intermediate compartment, which sequesters primary
spermatocytes away from basal and adluminal
compartments of the seminiferous epithelium.
Preleptotene/leptotene spermatocytes enter the adluminal
compartment when stable junctions ahead of
spermatocytes disassemble, while new junctions
assemble behind them. While there is enormous
restructuring of the seminiferous epithelium, the
mechanism of germ cell movement is incompletely
understood. In this perspective, the significance of
intercellular adhesion molecule-1 in the restructuring of
the blood-testis barrier during spermatogenesis in the
mammal is discussed.
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Citation
Histology and Histopathology, vol.31, nÂş2, (2016)
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