Publication: Antiangiogenic and radiotherapy for cancer treatment
Authors
Kobayashi, H. ; Lin, P.C.
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Publisher
Murcia : F. Hernández
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Description
Abstract
Tumor growth and progression depends on
tumor angiogenesis, the growth of tumor blood vessels,
therefore, targeting tumor angiogenesis is a very
promising approach for controlling tumor growth and/or
causing regression. Tumor blood vessels have been
recognized as a critical component of radiation response
to the point of being independent of tumor oxygenation
during radiation. An anti-angiogenic approach has been
considered less likely to develop drug resistance. But
recent findings suggest that anti-angiogenesis causes
hypoxia that selects tumor cells (due to genetic
instability) that are less dependent on blood supply and
leads to drug resistance. The approach of combination of
anti-angiogenesis with ionizing radiation by targeting
both endothelial and tumor cells should minimize this
possibility. The combination may produce a synergistic
anti-tumor effect.
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