Publication: Expression of the ets-1 proto-oncogene in
human breast carcinoma: Differential expression
with histological grading and growth pattern
Authors
Katayama, S. ; Nakayama, T. ; Ito, M. ; Naito, S. ; Sekine, I.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The proto-oncogene, ets-1, is a transcription
factor known to control the expression of a number of
genes and has been postulated to play a role in cell
growth, differentiation and tumour invasion. We
examined 137 cases of breast carcinoma by
immunohistochemistry and compared the degree of Ets-
1 expression among the different histological types of
invasive carcinomas. Ets-1 was not expressed in the
normal breast epithelium nor in noninvasive carcinomas.
Among the 137 breast carcinoma cases, 104 (83.2%)
showed positive staining for the Ets-1 protein.
Histologically, invasive ductal carcinomas expressed
immunopositivity with intense staining for Ets-1 in the
tumour cells. Ets-1 expression correlated with Bloom-
Richardson grading in invasive ductal carcinoma
(p<0.01). However, there was no correlation between
Ets-1 expression and lymph node metastasis, “t”
classification or TNM staging. In situ hybridization
confirmed the presence of Ets-1 mRNA in breast
carcinomas. The expression of Ets-1 mRNA was
detected in two of three different kinds of cultured
human breast carcinoma cell lines and one of three
human breast carcinoma tissues by the reverse
transcription polymerase chain reaction method. These
findings suggest that ets-1 is overexpressed in ductal
cells of the breast that have undergone malignant
conversion and that ets-1 is one of the factors associated
with tumour growth and histological differentiation of
breast carcinomas.
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