Publication: Immunoexpression of adhesion molecules during human fetal hair development
Authors
Andrade Silva, Laura Maria ; Hsieh, Ricardo ; Lourenço, Silvia Vanessa ; Ottoni, Verônica ; Valente, Neusa ; Dumet Fernandes, Juliana
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/ 10.14670/HH-18-224
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info:eu-repo/semantics/article
Description
Abstract
Introduction. Hair follicles are produced in a
cyclical manner and the machinery involved in the
reproduction of these follicles is present since the fetal
stage. Although extensive research has been done on the
human hair follicle, very little is known about the
importance of adhesion molecules in its development.
Material and methods. We analyzed here, the
immunoexpression of beta-1 integrin, p-cadherin, e-
cadherin, and beta-catenin in hair follicles from 26
formalin-fixed and paraffin-embedded skin samples
from human embryos and fetus between 12-23 weeks of
gestational age.
Results. The adhesion molecules beta-1 integrin and
e-cadherin/p-cadherin were expressed from 12 weeks
and seemed to play a role in regulating epidermis
invagination. Beta-catenin immunostaining was negative
in all cases; down regulation of this protein may be
necessary for fetal hair development and thus facilitating
hair follicle down growth.
Discussion/Conclusion. Adhesion molecules are
essential for hair follicle down growth and proliferation;
integrins and cadherins play a major role in this process.
More studies are needed to describe hair follicle
development
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Citation
Histology and Histopathology Vol. 35, nº8 (2020)
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