Publication: Expression of glutamine metabolism-related proteins in Hürthle cell neoplasm of thyroid: Comparison with follicular neoplasm
Authors
Cha, Yoon Jin ; Jang, Haerin ; Koo, Ja Seung
item.page.secondaryauthor
item.page.director
Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
publication.page.editor
publication.page.department
DOI
DOI: 10.14670/HH-18-036
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Purpose. We evaluated the expression of
glutaminolysis-related proteins in Hurthle cell
neoplasms (HCN) and follicular neoplasms (FN) of the
thyroid, and investigated its clinical implication.
Methods. Tissue microarrays were constructed from
264 FNs (112 follicular carcinomas [FCs] and 152
follicular adenomas [FAs]) and 108 HCNs (27 Hurthle
cell carcinomas [HCCs] and 81 Hurthle cell adenomas
[HCAs]. The immunohistochemical staining result of 3
glutaminolysis-related proteins (Glutaminase 1 [GLS1],
glutaminate dehydrogenase [GDH] and alanine- serine,
cysteine-preferring transporter 2 [ASCT2]) was
analyzed.
Results. GLS1 and GDH showed significantly
higher expression rates in HCN compared to FN
(P<0.001). More HCN cases showed co-positivity of
multiple glutaminolysis-related proteins than those of
FN cases (P<0.001). In silico analysis, both GLUD1 and
GLUD2 showed higher expression rate in HCA
compared to FA (P=0.027 and P=0.018, respectively).
SLC1A5 expression was highest in HCA, followed by
FC and FA (HCA vs FC, P=0.023; FC vs FA, P=0.002).
Conclusion. FN and HCN exhibit a different
expression pattern for glutaminolysis-related proteins,
and GLS1 and GDH have higher expression rates in
HCN and FN.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Este ítem está sujeto a una licencia Creative Commons. CC BY 4.0