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Expression of cyclooxygenase-2 has no impact on survival in adenocarcinoma of the esophagogastric junction but is associated with favourable clinicopathologic features

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dc.contributor.authorKnie, Juliana
dc.contributor.authorReddemann, Katharina
dc.contributor.authorPetrova, Ekaterina
dc.contributor.authorHerhahn, Tobias
dc.contributor.authorWellner, Ulrich
dc.contributor.authorThorns, Christoph
dc.date.accessioned2022-02-24T12:14:33Z
dc.date.available2022-02-24T12:14:33Z
dc.date.issued2017
dc.description.abstractBackground. COX-2 expression induces carcinogenesis and is thought to be an adverse prognostic factor in gastric carcinomas while the prognostic value of DNA mismatch repair (MMR) is still controversial. Concerning adenocarcinomas of the esophagogastric junction, no comprehensive data regarding either factors are available as of yet. Objective. We assessed expression of COX-2, MLH1 and MSH2 in adenocarcinoma of the esophagogastric junction in relation to patients’ survival and various clinicopathologic features. Design. Immunohistochemical studies (using antibodies against COX-2, MLH1 and MSH2) were performed in a study population of 228 tumours. Followup data was available for all patients with a mean follow-up time of 42.8 months. Results. 78 (34.2%) tumours were COX-2 negative, 148 (64.9%) showed COX-2 positivity. Assessment of COX-2 expression and clinicopathologic features revealed an inverse correlation with depth of tumour invasion and number of metastatic lymph nodes (p=0,021 and p=0,004, respectively). No correlation with other features could be demonstrated. 62 cases (27.2%) showed loss of DNA repair enzymes MLH1 and/or MSH2. MMR differed significantly between COX-2 positive and negative cases (p=0,028). KaplanMeier survival analyses revealed no impact on patients’ survival for COX-2 expression or MMR status (p=0.837 and p=0.972, respectively). Conclusions. Expression of COX-2 in adenocarcinomas of the esophagogastric junction seems to have no prognostic effect or impact on patients’ survival but is associated with favourable clinico-pathologic factors. MMR deficiency was more frequent in COX-2 negative tumours, but MMR status had no impact on survival and patients’ outcome whatsoeveres
dc.formatapplication/pdfes
dc.format.extent7es
dc.identifier.citationHistology and Histopathology, Vol.32, nº7, (2017)
dc.identifier.doiDOI: 10.14670/HH-11-843
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/117369
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCyclooxygenase-2es
dc.subjectCOX-2es
dc.subjectAdenocarcinoma of the esophagogastric junctiones
dc.subjectDNA mismatch repaires
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleExpression of cyclooxygenase-2 has no impact on survival in adenocarcinoma of the esophagogastric junction but is associated with favourable clinicopathologic featureses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.32, nº7 (2017)