Publication: CD26 dipeptidyl peptidase IV and its role in cancer
Authors
Pro, B. ; Dang, N.H.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
CD26/Dipeptidyl Peptidase IV (DPPIV) is a
110-kDa glycoprotein that is expressed on numerous cell
types and has multiple biological functions. A key facet
of CD26/DPPIV biology is its enzymatic activity and its
physical and functional interaction with other molecules.
The substrates of CD26/DPPIV are proline-containing
peptides and include growth factors, chemokines,
neuropeptides, and vasoactive peptides. DPPIV plays an
important role in immune regulation, signal transduction,
and apoptosis. Furthermore, CD26 appears to play an
important role in tumor progression. In the present
review, we summarize key aspects of CD26/DPPIV
involvement in tumor biology and its potential role in
cancer development and behavior.
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