Publication: The combination of strong
immunohistochemical mtTFA expression
and a high survivin index predicts a shorter diseasespecific survival in pancreatic ductal adenocarcinoma
Authors
Kimura, Tomoko ; Kitada, Shohei ; Uramoto, Hidetaka ; Zhi, Li ; Kawatsu, Yuichiro ; Takeda, Toru ; Horie, Seichi ; Nabeshima, Atsunori ; Noguchi, Hirotsugu ; Sasaguri, Yasuyuki ; Izumi, Hiroto ; Kohno, Kimitoshi ; Yamada, Sohsuke
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
https://doi.org/10.14670/HH-30.193
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info:eu-repo/semantics/article
Description
Abstract
Mitochondrial transcription factor A
(mtTFA) plays a crucial role in both the transcription and
maintenance of mitochondrial DNA. A high expression
of mtTFA has been demonstrated in several solid tumors,
and is closely associated with cancer cell
survival/apoptosis and growth. However, its expression
pattern in pancreatic ductal adenocarcinoma (PAC)
remains to be elucidated. Additionally, our groups have
recently revealed that a subset of apoptosis-related genes
is strongly regulated by mtTFA, and that two putative
mtTFA binding sites are present in the promoter region
of the survivin gene, which is a member of the inhibitorof-apoptosis protein family. We therefore investigated
the correlation of the immunohistochemical mtTFA
expression and the survivin index with various
clinicopathological variables and the prognosis, using 70
paraffin-embedded tumor samples from patients with
surgically-resected PAC. The mtTFA expression or
survivin index was considered to be strong or high when
≥30% or 10% of the PAC cells showed positive staining,
respectively. Strong mtTFA expression and/or a high
survivin index was revealed to have a significant
relationship to a pathologically high tumor grading and
advanced tumor stage. Moreover, mtTFA showed
significantly high co-expression with survivin.
Univariate and multivariate analyses demonstrated that
both the strong mtTFA expression and high survivin
index groups had significantly shorter survival rates,
especially within the first two years postoperatively. The
combination of strong mtTFA expression and a high
survivin index may predict a poor prognosis in patients
with PAC, and these new biomarkers might offer useful
information for the early clinical management.
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