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Infection through structured polymicrobial Gardnerella biofilms (StPM-GB)

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dc.contributor.authorSwidsinsk, Alexander
dc.contributor.authorLoening-Baucke, Vera
dc.contributor.authorMendling, Werner
dc.contributor.authorDörffel, Yvonne
dc.contributor.authorSchilling, Johannes Schilling
dc.contributor.authorHalwani, Zaher
dc.contributor.authorJiang, Xue-feng
dc.contributor.authorVerstraelen, Hans
dc.contributor.authorSwidsinski, Sonja
dc.date.accessioned2019-03-28T12:01:00Z
dc.date.available2019-03-28T12:01:00Z
dc.date.issued2014
dc.description.abstractBACKGROUND: We analysed data on bacterial vaginosis (BV) contradicting the paradigm of mono-infection. METHODOLOGY: Tissues and epithelial cells of vagina, uterus, fallopian tubes and perianal region were investigated using fluorescence in situ hybridization (FISH) in women with BV and controls. RESULTS: Healthy vagina was free of biofilms. Prolific structured polymicrobial (StPM) Gardnerella-dominated biofilm characterised BV. The intact StPM-Gardnerellabiofilm enveloped desquamated vaginal/prepuce epithelial cells and was secreted with urine and sperma. The disease involved both genders and occurred in pairs. Children born to women with BV were negative. Monotherapy with metronidazole, moxifloxacin or local antiseptics suppressed but often did not eradicate StPMGardnerella-biofilms. There was no BV without Gardnerella, but Gardnerella was not BV. Outside of StPM-biofilm, Gardnerella was also found in a subset of children and healthy adults, but was dispersed, temporal and did not transform into StPM-Gardnerella-biofilm. CONCLUSIONS: StPM-Gardnerella-biofilm is an infectious subject. The assembly of single players to StPM-Gardnerella-biofilm is a not trivial every day process, but probably an evolutionary event with a long history of growth, propagation and selection for viability and ability to reshape the environment. The evolutionary memory is cemented in the structural differentiation of StPM-Gardnerella-biofilms and imparts them to resist previous and emerging challengees
dc.formatapplication/pdfes
dc.format.extent21es
dc.identifier.citationHistology and Histopathology, vol. 29, nº 5, (2014)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/68601
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectBacterial vaginosises
dc.subjectStructured polymicrobial Gardnerella dominated bacterial biofilmes
dc.subjectAntibiotic resistancees
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleInfection through structured polymicrobial Gardnerella biofilms (StPM-GB)es
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.29, nº 5 (2014)