Publication: Aberrant expression of a fetal glycoprotein 68 in hepatocellular
carcinoma: a comparative study on the expression
of alpha-fetoprotein and carcinoembryonic antigen
Authors
Kato, Massuo J. ; Shinozawa, T. ; Kato, S. ; Terada, T.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
A rat IgG2a monoclonal antibody against a
stage-specific fetal glycoprotein with a molecular mass
of 68 kDa (FGP68) was produced and applied to paraffin
sections. This monoclonal antibody was used to compare
the expression of FGP68 with that of both alphafetoprotein
(AFP) and carcinoembryonic antigen (CEA)
in 75 hepatocellular carcinomas (HCCs). Seventy-five
primary HCCs from patients aged 36 to 77 years were
examined. Formalin-fixed, paraffin-embedded tissue
sections were used for immunohistochemical analyses.
Histologically, 6 cases of HCC were classified as type I
according to the Edmondson and Steiner criteria, 57
cases as type II, and 12 cases as type III. The cancer
tissues showed positive reactions with the antibody
against FGP68. Approximately one-third of the HCCs
(26/75) contained tumor cells that expressed FGP68 -
(21/57 for Edmondson and Steiner type II; 4/12 for type
III; and 1/6 for type I) - and positive immunoreactivity
was observed in the cytoplasm of the cancer cells.
Twenty-five of the 75 HCCs had tumor cells that
expressed AFP and there was a significant correlation
between FGP68 expression and AFP expression.
Twenty-three of the 75 HCCs had tumor cells that
expressed CEA and there was no significant correlation
between FGP68 expression and CEA expression. No
positive reactions for FGP68, AFP and CEA were
observed in samples of non-neoplastic liver tissues. Based on the possibility that stage-specific FGP68 plays
an important role in liver embryogenesis, FGP68-
expressing tumor cells might ontogenetically revert to
more primitive cells.
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