Publication: Effect of telmisartan on preexistent cardiac and renal lesions in spontaneously hypertensive mature rats
Authors
Mandarim-de-Lacerda, Carlos A. ; Pereira, L.M.M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Fifteen adult male spontaneously
hypertensive rats (one year old) (SHR) were separated
into three groups (n=5 each) during 15 weeks as follows:
initial control group (IC); final control group (FC); and
telmisartan group (T) (1.2 mg/kg/day of telmisartan).
Serum and urinary creatinine and proteinuria were not
different comparing untreated and telmisartan-treated
SHRs. FC rats showed a continuous BP increase during
the study while T rats reached the 15th week with a
significantly low BP. The LV mass index was
significantly smaller in the T group than in the FC
group, as was the glomerular hypertrophy. The
cardiomyocyte nuclei density per area and the
cardiomyocyte mean cross-sectional area were smaller in
the T group than in both the IC and FC groups.
Intramyocardial artery densities (per area and per
volume) were greater in the T group than in untreated
SHRs, but myocardial fibrosis was reduced. In
conclusion, telmisartan monotherapy effects on BP and
also on the hypertension target organs, heart and kidney,
are favorable. Telmisartan is able to attenuate SHR
cardiomyocyte and glomerular hypertrophies, and
myocardial reactive fibrosis as well. It also is favorable
to the intramyocardial microcirculation.
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