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Abnormal collagen deposition in synovia after collagen type V immunization in rabbits

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dc.contributor.authorTsuzuki Ichicawa Ogido, Lucianaes
dc.contributor.authorWalcy Rosolia, Teodoroes
dc.contributor.authorPereira Velosa, Ana Paula
dc.contributor.authorDe Oliveira, Cristiane Carla
dc.contributor.authorRoger Parra, Edwin
dc.contributor.authorCapelozzi, Vera Luiza
dc.contributor.authorHajime Yoshinari, Natalino
dc.date.accessioned2013-01-18T12:21:25Z
dc.date.available2013-01-18T12:21:25Z
dc.date.issued2008
dc.description.abstractSinovitis in Scleroderma (SSc) is rare, usually aggressive and fully resembles rheumatoid arthritis. Experimental models of SSc have been used in an attempt to understand its pathogenesis. Previous studies done in our laboratory had already revealed the presence of a synovial remodeling process in rabbits immunized with collagen V. To validate the importance of collagen type V and to explore the quantitative relationship between this factor and synovia remodeling as well as the relationship between collagen type V and other collagens, we studied the synovial tissue in immunized rabbits. Rabbits (N=10) were immunized with collagen V plus Freund’s adjuvant and compared with animals inoculated with adjuvant only (N=10). Synovial tissues were submitted to histological analysis, immunolocalization to collagen I, III and V and biochemical analysis by eletrophoresis, immunoblot and densitometric method. The synovial tissue presented an intense remodeling process with deposits of collagen types I, III and V after 75 and 120 days of immunization, mainly distributed around the vessels and interstitium of synovial extracellular matrix. Densitometric analysis confirmed the increased synthesis of collagen I, III and V chains (407.69±80.31; 24.46±2.58; 70.51±7.66, respectively) in immunized rabbits when compared with animals from control group (164.91±15.67; 12.89±1.05; 32±3.57) (p<0.0001). We conclude that synovial remodeling observed in the experimental model can reflect the articular compromise present in patients with scleroderma. Certainly, this experimental model induced by collagen V immunization will bring new insights in to pathogenic mechanisms and allow the testing of new therapeutic strategies to ameliorate the prognosis for scleroderma patients.es
dc.formatapplication/pdfes
dc.format.extent7es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/29677
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectCollagenes
dc.subjectFibrosises
dc.subject.other616.7 - Patología de los órganos de la locomoción. Sistema locomotor y esqueléticoes
dc.titleAbnormal collagen deposition in synovia after collagen type V immunization in rabbitses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.23, nº3 (2008)