Publication: Immunoexpression of the hepatocyte
growth factor (HGF), HGF-receptor (c-met) and
STAT3 on placental tissues from malformed fetuses
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Date
2002
Authors
Trovato, M. ; Grosso, Maddalena ; Vitarelli, E. ; Benvenga, S. ; Trimarchi, F. ; Barresi, G.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
To characterize the possible relationship
between the expression of the HGF/HGF-R system with
transcription factor STAT3, responsible for
morphogenetic response of HGF stimulation, and the
embryonic development alterations, we investigated, by
immunohistochemistry, the expression of HGF, c-met
and STAT3 in 9 placentas from malformed fetuses and 9
control placentas from non-malformed fetuses.
The major and distinct patterns of expression
characterizing the placentas from malformed fetuses
were a higher percentage mean of stromal cells stained
for HGF, c-met and STAT3 antibodies (60%, 66% and
54%, respectively on fibroblast cells and 44%, 57% and
42%, respectively on myofibroblast cells) and a lower
percentage mean of cytotrophoblast cells stained for the
same antibodies (2%, 2% and 1%, respectively), than in
control placentas. In fact, in this latter group, the stromal
fibroblast cells were stained in a percentage mean of
27%, 22% and 7%, respectively; the stromal
myofibroblast cells in a percentage mean of 5%, 6% and
2%, respectively and the cytotrophoblast cells in a
percentage mean of 25%, 34% and 18%, respectively.
The expression of each antibody on stromal cells in
both groups suggests an alternative role of the
HGF/HGF-R system activating the via STAT3
transdution and operating on placental tissues, overall in
organogenesis alteration conditions.
This immunohistochemical approach could be used
in the diagnostic practice of pathologists on chorionic
villi biopsy when genetic alterations are absent and
ultrasound aspects are doubtful for malformations.
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