Publication: The history and histology of bone morphogenetic protein
Authors
Murray, Samuel S. ; Brochmann Murray, Elsa J. B ; Wang, Jeffrey C. ; Leite Duarte, Maria Eugenia
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Publisher
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DOI
DOI: 10.14670/HH-11-774
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info:eu-repo/semantics/article
Description
Abstract
Bone morphogenetic proteins are a group of
structurally related proteins within the TGF-β
superfamily of proteins with a diverse repertoire of
functions in embryonic and adult organisms. As is
apparent from the name, the members first characterized
participate in bone growth, development, and
remodeling. The “morphogenic” activity per se is
defined as the induction of a recapitulation of
endochondral bone formation by appropriate stem cells.
The regenerative capacity of bone has been recognized
since ancient times. The mechanism, applications, and
conceptual basis of bone transplantation, bone
implantation, ectopic bone formation, and exogenously
induced bone formation have been studied by many
investigators for more than a century. This review
examines the efforts to characterize this activity in the
European and American literature over approximately
the last century. Because of the inherently complex
nature of the process induced by these molecules
(inflammation, stem cell proliferation, cartilage
differentiation, replacement of cartilage with bone) it is
important to evaluate previous investigations through a
histological perspective. The cellular basis of the
contemporary bioassay for BMP activity is illustrated
and discussed from the histological point of view.
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Citation
Histology and histopathology: Vol.31, nº7 (2016)
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