Publication:
Occurrence of pancreatic ductal cell dysplasia in rats fed with a high fat diet and ethanol

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dc.contributor.authorJalovaara, P.es
dc.contributor.authorRämö, J.es
dc.contributor.authorApaja-Sarkkinen, M.
dc.date.accessioned2011-01-17T12:39:25Z
dc.date.available2011-01-17T12:39:25Z
dc.date.issued1986
dc.description.abstractThe effects of alcohol and diet on acute pancreatitis were studied in 192 male Wistar rats. The animals were fed with standard laboratory food up to three months of age and, after that, were divided into four groups of 48 animals,each group receiving a different diet: standard, fat-rich, protein-rich or carbohydrate-rich. In each diet group, 24 animals obtained 15% (v/v) ethanol in their drinking solution while the other 24 rats had water ad libitum. The diet period lasted for 12 weeks, after which acute experimental pancreatitis was induced under diethyl ether anesthesia by ductal injection of rat bile into the pancreatic ducts. Moderate or severe ductal cell dysplasia developed in three of the 15 survivors in the group fed with a high-fat diet and 15% ethanol in their drinking solution. Mild acute pancreatitis was histologically found in 13 rats and moderate pancreatitis in one rat in this group. One rat did not show any pancreatic parenchyma1 changes. Two of the rats with ductal cell dysplasia had mild pancreatitis and the pancreas of the third rat was normal in this respect. Dysplastic changes were not found in any other experimental group used in the study. The observation is statistically significant at p < 0.025 level. The results indicate that alcohol and a high fat diet together might have a carcinogenic effect on pancreatic ductal epithelium in rats.en_EN
dc.formatapplication/pdfes
dc.format.extent6es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/17833
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectPancreases
dc.subjectDuctal cell dysplasiaes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleOccurrence of pancreatic ductal cell dysplasia in rats fed with a high fat diet and ethanoles
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol. 1, nº 4 (1986)