Publication: Histopathological prognostic factors for
colorectal liver metastases: A systematic
review and meta-analysis of observational studies
Authors
Cavalcante de Oliveira, Cássio Virgílio ; Marques Fonseca, Gilton ; Pirola Kruger, Jaime Arthur ; Sobroza de Mello, Evandro ; Ferreira Coelho, Fabricio ; Herman, Paulo
item.page.secondaryauthor
item.page.director
Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
publication.page.editor
publication.page.department
DOI
https://doi.org/10.14670/HH-18-274
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Introduction. Resection is the mainstay of
treatment for colorectal liver metastases (CRLMs).
Many different histopathological factors related to the
primary colorectal tumour have been well studied;
however, histopathological prognostic factors related to
CRLMs are still under evaluation. Objective. To identify
histopathological factors related to overall survival (OS)
and disease-free survival (DFS) in patients with resected
CRLMs.
Methods. A systematic review was performed with
the following databases up to August 2020: PubMed,
EMBASE, Web of Science, SciELO, and LILACS. The
GRADE approach was used to rate the overall certainty
of evidence by outcome.
Results. Thirty-three studies including 4,641 patients
were eligible. We found very low certainty evidence that
the following histopathological prognostic factors are
associated with a statistically significant decrease in OS:
presence of portal vein invasion (HR, 410.50 [95% CI,
0.37 to 0.68]; I2=0%), presence of perineural invasion
(HR, 0.55 [95% CI, 420.36 to 0.83]; I2=0%), absence of
pseudocapsule (HR, 0.41 [CI 95%, 0.29 to 0.57],
p<0.00001; I2=0%), presence of satellite nodules (OR,
0.45 [95% CI, 0.26 to 0.80]; I2=0%), and the absence of
peritumoural inflammatory infiltrate (OR, 0.20 [95% CI,
0.08 to 0.54]; I2=0%). Outcome data on DFS were
scarce, except for tumour borders, which did not present
a significant impact, precluding the meta-analysis.
Conclusion. Of the histopathological prognostic
factors studied, low- to moderate-certainty evidence
shows that vascular invasion, perineural invasion,
absence of pseudocapsule, presence of satellite nodules,
and absence of peritumoral inflammatory infiltrate are
associated with shorter overall survival in CRLMs.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Este ítem está sujeto a una licencia Creative Commons. CC BY 4.0