Publication: The role of vascular adhesion molecules
PECAM-1 (CD 31), VCAM-1 (CD 106), E-Selectin (CD62E)
and P-Selectin (CD62P) in severe porcine pancreatitis
Authors
Kleinhans, Helge ; Kaifi, Jussuf T. ; Mann, Oliver ; Reinknecht, Felix ; Freitag, Marc ; Hansen, Bente ; Schurr, Paulus G. ; Izbicki, Jacob R. ; Strate, Tim G.
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Publisher
Murcia: F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Inflammatory cytokines have been shown to
mediate organ damage by their action on vascular
endothelia and leukocytes, in part by upregulating the
expression of adhesion molecules, which in turn convey
transmigration of leukocytes into tissue.
The upregulation and activation of vascular cell
adhesion molecules on the endothelial cells avail firm
leukocyte adhesion to the vascular endothelium and
enhance their transmigration and consecutive tissue
injury. The aim of this study was to evaluate the
expresion of vascular adhesion molecules CD 31
(PECAM-1), CD 106 (VCAM-1), CD 62E (E-Selectin)
and CD 62P (P-Selectin) in the pancreas and distant
organs of pigs suffering from acute necrotizing
pancreatitis (AP).
AP was induced in 13 pigs by a combination of
intravenous cerulein and intraductal glycodeoxycholic
acid. For immunostaining of vascular adhesion
molecules slides of porcine pancreas, lung, kidney and
liver tissue were stained with monoclonal antibodies
(Ab) against PECAM-1-1, VCAM-1 E- and PSELECTIN.
The endothelial cell expression of CD 31 (PECAM-
1), CD 106 (VCAM), CD 62E (E-Selectin) and CD 62P
(P-SELECTIN) in severe porcine pancreatitis is
detectable and upregulation is partly significantly.
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