Publication: Effect of sulfur dioxide on vascular biology
Authors
Cai, Huijun ; Wang, Xinbao
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-290
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info:eu-repo/semantics/article
Description
Abstract
Gasotransmitters, such as nitric oxide, carbon
monoxide and hydrogen sulfide, can be generated
endogenously. These gasotransmitters play important
roles in vascular biology, including vasorelaxation and
inhibition of vascular smooth muscle cell (VSMC)
proliferation. In recent years, sulfur dioxide (SO2) has
been considered as the fourth gasotransmitter. SO2 is
present in air pollution. Moreover, SO2 toxicity,
including oxidative stress and DNA damage, has been
extensively reported in previous studies. Recent studies
have shown that SO2 can be endogenously generated in
various organs and vascular tissues, where it regulates
vascular tone, vascular smooth cell proliferation and
collagen synthesis. SO2 can decrease blood pressure in
rats, inhibit smooth muscle cell proliferation and
collagen accumulation and promote collagen
degradation, and improve vascular remodelling. SO2 can
decrease cardiovascular atherosclerotic plaques by
enhancing the antioxidant effect and upregulating nitric
oxide/nitric oxide synthase and hydrogen sulfide/
cystathionine-γ-lyase pathways. SO2 can also ameliorate
vascular calcification via the transforming growth factor
- β1/Smad pathway. The effect of SO2 on vascular
regulation has attracted great interest. SO2 may be a
novel mediator in vascular biology
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