Publication: The distribution of peptide-containing nerves in the synovia of the cat knee joint
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Date
1991
Authors
Abramobici, A. ; Daizade, I. ; Yosipovitch, Z. ; Gibson, S.J. ; Polak, J.M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Synovial capsule in cats is extensively
innervated by a network with axonal diameter ranging
from 0.6-3 pm according to its position and neuropeptide
content. Nerve markers such as Neuron Specific Enolase
(NSE) and Neurofilament triplet protein (NF) could be
observed only when the axonal fibre attained a critical
diameter of over the 3 pm limit. The relatively thick
fibres (1-3 pm) show positive immunoieactivity for
Substance P (SP), 5-hydroxytryptamine (5-HT). and
Vasoactive Intestinal Peptide (VIP), and seldom coreact
with NSE and NF. whereas, the thinnest fibres (0.6-0.8
pm) characterized to contain either Methionine or
Leucine Enkephalin (M-Enk, L-Enk) did not coreact
positively with axonal markers.
We found that different anesthetics may effect
variably the immunoreactivity of some neuropeptides
(SP. L-Enk, 5-HT) while others (VIP, M-Enk) remained
unaffected. Based on our data and the few reported ones
in the pertinent literature, it is judged that urethane
is the anesthetic of choice in experimental studies of
neuropeptides.
Our findings of isolated positive immunoreactive cell
bodies to enkephalin in synovia might suggest the
presence of intrinsic relay system, where the enkephalin
acts as suppressor of SP and VIP release from the
sunovium nerve terminals. Such a local inter-relationship
between different neuropeptide systems might have a
practical role on the understanding of the pathogenesis
of different arthritic processes as well as therapeutic
strategy in the future.
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