Publication: The effect of the flavonoid diosmin, grape seed extract and red wine on the
pulmonary metastatic B16F10 melanoma
Authors
Martínez, C. ; Vicente García, Vicente ; Yáñez, J. ; Alcaraz, M. ; Canteras, M. ; Benavente-García García, Obdulio ; Castillo, J. ; Castells Mora, María Teresa
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Objective: To study the effect of different
phenolic compounds and red wine on pulmonary
metastatic melanoma. Methods: Swiss mice were
inoculated with 5x105 melanocytes B16F10 and given
oral doses of diosmin, grape seed extract (GSE) and red
wine. A macroscopic count was made of the metastatic
nodules on the lung surface and a microscopic study by
image analysis of five sections, calculating the
implantation percentage and tumoral growth and
invasion indices. Results: Macroscopically, the group
treated with diosmin showed the greatest reduction
(52%) in the number of metastatic nodules compared
with the control group, which was treated with ethanol,
while GSE and red wine caused decreases of 26.07 and
28.81%, respectively. Microscopically, there was a
decrease in the implantation percentage after the
administration of diosmin (79.4%) and red wine
(20.19%), and an increase of 2.12% after the
administration of GSE, all relative to the ethanol-treated
control. As regards the growth index, diosmin produced
a reduction of 67.44% and red wine a reduction of
20.62%, while GSE again produced an increase
(25.33%). The reductions in the invasion index were
45.23, 31.65 and 17.57% with diosmin, GSE and red
wine, respectively. Conclusions: Diosmin originated the
greatest reduction in pulmonary metastases, both at the
macroscopic and microscopic levels.
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