Publication: Involvement of resistance to apoptosis in the pathogenesis of endometriosis
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Date
2009
Authors
Nasu, K. ; Yuge, A. ; Tsuno, A. ; Nishida, M. ; Narahara, H.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Endometriosis, a disease affecting 3-10% of
women of reproductive age, is characterized by the
ectopic growth of endometrial tissue. Increasingly,
endometriosis is also becoming recognized as a
condition in which ectopic endometrial cells exhibit
abnormal proliferative and apoptotic regulation in
response to appropriate stimuli.
Apoptosis plays a critical role in maintaining tissue
homeostasis and represents a normal function to
eliminate excess or dysfunctional cells. Accumulated
evidence suggests that, in healthy women, endometrial
cells expelled during menstruation do not survive in
ectopic locations because of programmed cell death,
while decreased apoptosis may lead to the ectopic
survival and implantation of these cells, resulting in the
development of endometriosis. Both the inability of
endometrial cells to transmit a ‘death’ signal and the
ability of endometrial cells to avoid cell death have been
associated with increased expression of anti-apoptotic
factors and decreased expression of pre-apoptotic
factors.
This paper is a review of the recent literature
focused on the differential expression of apoptosisassociated molecules in the normal endometria of
women without endometriosis, and in the eutopic and
ectopic endometria of women with endometriosis. The
role of apoptosis in the pathogenesis of endometriosis
and the basic and clinical research on the current
medical treatment for endometriosis from the view of
apoptosis will be discussed.
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