Publication: Expression of hexokinases and glucose transporters in treated and untreated oesophageal adenocarcinoma
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Date
2009
Authors
Fonteyne, Philippe ; Casneu, Veerle ; Pauwels, Patrick ; Van Damme, Nancy ; Peeters, Marc ; Dierckx, Rudi ; Van de Wiele, Christophe
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The aim of this study was to assess the
expression pattern of the high glucose affinity glucose
transporters GLUT 1, 2, 3, 4, 8 and 9 and of hexokinases
I, II and III in newly diagnosed oesophageal
adenocarcinoma by means of immunohistochemistry.
Twenty patients eligible to undergo primary surgery
and 18 patients with incomplete pathological response
following induction radio chemotherapy, all suffering
from oesophageal adenocarcinoma, were included in the
study. The intensity and amount of positive tumour cells
in the immuno-reaction (histology score (Hscore)) for
GLUT 1, 3, 4, 8 and 9 as well as for hexokinase I, II and
III were assessed independently by two experienced
observers, blinded to the clinical results.
In patients that underwent primary surgery, Hscores
of GLUT8 (µ 6.7; sd3.3) and GLUT1 (µ 5.5; sd: 5.3)
were significantly higher than Hscores of GLUT9 (µ 2.2;
sd 1.5) and GLUT3 (µ 3.2, sd: 2.5). Hscores of
hexokinase I (µ : 8.3; sd: 4.3), II (µ 5.5, sd: 4.0) and III
(Ì 1.5, sd: 0.7) were all significantly different from each
other (p<0.04). In patients that underwent radiochemotherapy prior to surgical tumour resection, µ
Hscores were 6.9 (sd: 4.4) for GLUT1, 6.8 (sd: 5.3) for
GLUT3, 5.9 (sd: 4.2) for GLUT8, 3.4 for GLUT9 (sd:
2.7) and 2.3 (sd: 3.6) for GLUT 4. Hscores of GLUT1
and GLUT3 were significantly higher than Hscores of
GLUT4. Finally, Hscores of patients with radiochemotherapy for GLUT3, hexokinase II and III were
significantly higher when compared to patients that
underwent primary surgery.
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