Publication: Expression of matrix metalloproteinase-9 (gelatinase B) in benign, premalignant and malignant laryngeal lesions
Authors
Peschos, D. ; Damala, C. ; Stefanou, D. ; Tsanou, E. ; Assimakopoulos, D. ; Vougiouklakis, T. ; Charalabopoulos, K. ; Agnantis, N.J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The matrix metalloproteinases (MMPs) are a
family of proteolytic zinc-containing enzymes, which
are responsible for the breakdown of the extracellular
matrix components in pathological and physiological
conditions. They are involved in basement membrane
disruption, stroma and blood vessel penetration,
metastasis and more recently there is evidence that they
participate in tumor growth and angiogenic events.
Matrix metalloproteinase 2 and 9 (MMP 2 and 9) belong
to the gelatinases, a subgroup of MMPs, and have the
capacity to degrade the triple helix type IV collagen of
basal lamina of the basement membrane. With the
present study, we tried to demonstrate the expression of
MMP-9 immunohistochemically, comparatively in
benign, premalignant and malignant lesions of the
larynx. We studied 154 laryngeal lesions including 55
squamous cell carcinomas, 8 in situ carcinomas, 54 cases
of dysplasia (of low and intermediate grade), 13
papillomas and 24 cases of keratosis. Overexpression of
MMP 9 was observed in 74.4% and 50% in invasive and
in situ squamous cell carcinomas respectively. In
dysplastic cases, in papillomas and in keratoses the
percentage of overexpression was 62.9%, 61.53% and
54.16% respectively and the expression of MMP-9 was significantly higher in invasive squamous cell
carcinomas compared to dysplasias (p=0.000004). Also
significantly higher was the expression of MMP-9 in
dysplastic cases compared to papillomas (p=0.023). The
MMP-9 expression was related neither to survival nor to
the other available clinicopathological parameters
(tumor size, grade, clinical stage, lymph node status and
patient age). In conclusion, our study indicates that the
expression of MMP-9 is up-regulated in a stepwise
fashion, with two main steps, the first one, when a
dysplastic lesion evolves and the next one, when the
dysplasia progresses to invasive carcinoma.
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