Publication: Mechanisms underlying estrogen-induced sexual differentiation in the hypothalamus
Loading...
Date
2006
Authors
Ohtani-Kaneko, R.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Estrogen plays critical roles in the sexual
differentiation of the developing brain and genderspecific
regulation of reproductive neuroendocrinology.
Of the different regions of the brain, it is well known
that hypothalamic areas contain key sexually
differentiated neuronal circuits. Estrogen receptor (ER)
proteins localized in the nucleus affect the expression of
target genes when bound to their ligand estrogen.
However, recent studies suggest that this may not be the
only mechanism of estrogen action. Instead, estrogen
can influence various cellular events through regulating
different signaling pathways. Cross-talk between direct
effects of estrogen on gene transcription and its effects
on signaling pathways should be examined in future to
elucidate mechanisms underlying sexual differentiation
in the hypothalamus.
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.