Publication: Different expression of the catalytic alpha
subunits of the AMP activated protein kinase -
an immunohistochemical study in human tissue
Authors
Quentin, Thomas ; Kitz, Julia ; Steinmetz, Michael ; Poppe, Andrea ; Bär, Karin ; Krätzner, Ralph
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Publisher
Murcia: F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Summary. AMPK is an ubiquitously distributed
multienzyme complex. It is an important energy sensor
and regulator of cellular metabolic activity. In this study
we analyzed for the first time the cellular distribution of
the catalytically active subunits AMPKα1 and α2 in
different human tissues by immunohistochemistry. We
found different expression patterns for both isoforms.
AMPKα2 expression clearly dominates in skeletal
myocytes and cardiomyocytes, whereas AMPKα1
dominates in a number of secreting cells, like mammary
glands, islets of langerhans and cells of the colon crypts.
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