Publication: MUC-1-ESA+ progenitor cells in normal benign and malignant human breast epithelial cells
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Date
2009
Authors
Lu, Xinquan ; Li, Huixiang ; Xu, Kejia ; Nesland, Jahn M. ; Suo, Zhenhe
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The existence of mammary epithelial
stem/progenitor cells has been demonstrated in MUC-1-/
ESA+ subpopulations of breast epithelial cells. However,
knowledge about the expression and localization in
benign and malignant breast lesions is unknown. Using a
double-staining immunohistochemistry method, we
investigated MUC-1-/ESA+ cells in 10 normal breast
tissues, 49 cases with fibrocystic disease, 40
fibroadenomas, 36 invasive ductal carcinomas and the
breast cancer cell lines MCF-7 and MDA-MB-468. In
normal breast tissues MUC-1-/ESA+ cells were mainly
found in the suprabasal layer, but under the apical
surface of the duct/alveolus. In the hyperplastic areas of
fibrocystic disease, the number of this subpopulation of
cells was higher than that in hypoplastic areas and in
fibroadenomas. In invasive ductal carcinoma, the
MMUC-1-/ESA+ cells were heterogeneously present in
different carcinoma nests. In the MCF-7 cell line most
cells were MUC-1-/ESA+, and in the MDA-MB-468 cell
line MUC-1-/ESA+ cells and MUC-1-/ESA+ cells were
almost equal. Our results show that the MUC-1-/ESA+
subpopulation increases in fibrocystic disease within the
hyperplastic areas, and varies in benign and malignant
breast tumours, indicating that breast carcinogenesis
may develop from malignant changes of normal
MUC-1-/ESA+ cells.
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