Publication: Crim1–, a regulator of developmental organogenesis
Authors
Iyer, Swati ; Pennisi, David J. ; Piper, Michael
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
DOI: 10.14670/HH-11-766
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info:eu-repo/semantics/article
Description
Abstract
The regulation of growth factor localization,
availability and activity is critical during embryogenesis
to ensure appropriate organogenesis. This process is
regulated through the coordinated expression of growth
factors and their cognate receptors, as well as via
proteins that can bind, sequester or localize growth
factors to distinct locations. One such protein is the
transmembrane protein Crim1. This protein has been
shown to be expressed broadly within the developing
embryo, and to regulate organogenesis within the eye,
kidney and placenta. Mechanistically, Crim1 has been
revealed to mediate organogenesis via its interaction
with growth factors including TGFβs, BMPs, VEGFs
and PDFGs. More recently, Crim1 has been shown to
influence cardiac development, providing further
insights into the function of this protein. This review will
provide an overview of the role of Crim1 in
organogenesis, largely focusing on how this protein
regulates growth factor signaling in the nascent heart.
Moreover, we will address the challenges ahead relating
to further elucidating how Crim1 functions during
development.
Citation
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