Publication: Expression pattern of squamous cell carcinoma antigen in oesophageal dysplasia and squamous cell carcinoma
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Date
2007
Authors
Parenti, Anna ; Porzionato, A. ; Pizzi, S. ; Guzzardo, V. ; Fassina, G. ; Macchi, Verónica ; Ninfo, V. ; De Caro, Raffaelle
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The aim of the present study was to evaluate
the tissue expression of squamous cell carcinoma
antigen (SCCA) in oesophageal dysplasia and squamous
cell carcinoma (SCC) with reference to its clinicopathologic
and prognostic significance. Immunohistochemistry
using SCCA polyclonal antibody was
performed on SCCs from 61 surgical oesophagectomies.
Fifteen cases of low-grade dysplasia (LGD) and 37 noncoexistent
high-grade dysplasia (HGD) were also
sampled from these materials, together with sixteen
chronic cases of oesophagitis. SCCA immunoreactivity
was present in the maturative compartments of all
normal epithelia and oesophagitis. LGDs showed no
SCCA immunoreactivity in the dysplastic proliferative
component but only in the superficial normal layers. In
94.6% of HGDs, no SCCA immunoreactivity was
detected throughout the thickness of the epithelium. In
SCCs, SCCA expression higher than 25% was found in
54% of cases. SCCA positivity showed an inverse
correlation with histological grade, whereas no
statistically significant correlation was found with TNM
classifications, stage, or survival. SCCA is not expressed
in early oesophageal carcinogenesis but, in SCC, it
represents an indicator of histologic differentiation. In
differentiated SCC, SCCA may represent a negative
factor for cancer invasiveness, through inhibition of
proteases
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