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Liver fibrosis: a dynamic and potentially reversible process

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dc.contributor.authorPovero, Davidees
dc.contributor.authorBusletta, Chiaraes
dc.contributor.authorNovo, Erica
dc.contributor.authorValfrè di Bonzo, Lorenzo
dc.contributor.authorCannito, Stefania
dc.contributor.authorPaternostro, Claudia
dc.contributor.authorParola, Maurizio
dc.date.accessioned2015-09-29T07:18:02Z
dc.date.available2015-09-29T07:18:02Z
dc.date.issued2010
dc.description.abstractIn any chronic liver disease (CLDs), whatever the aetiology, reiteration of liver injury results in persisting inflammation and progressive fibrogenesis, with chronic activation of the wound healing response in CLDs, representing a major driving force for progressive accumulation of ECM components, eventually leading to liver cirrhosis. Cirrhosis is characterized by fibrous septa dividing the hepatic parenchyma into regenerative pseudo-lobules, as well as by extensive changes in vascular architecture, the development of portal hypertension and related complications. Liver fibrogenesis (i.e., the dynamic process leading to increased deposition of ECM and much more) can lead to different patterns of fibrosis and is sustained by myofibroblast-like cells (MFs) of different origin, with activated hepatic stellate cells (HSC/MFs) being the major cell type involved. Major pro-fibrogenic mechanisms also include oxidative stress, as well as derangement of epithelial-mesenchymal interactions and, as recently suggested, the process of epithelial to mesenchymal transition (EMT). Liver fibrosis has been considered traditionally as an irreversible process but experimental and clinical literature data published in the last decade have suggested that both the removal of the aetiological agent or condition, as well as an effective therapy, can result in significant regression of liver fibrosis. This is usually associated, particularly in animal models, with induction of apoptosis in MFs but, unfortunately, human HSC/MFs are much more resistant to apoptosis than murine MFs. However, clinical studies provided no unequivocal evidence for a complete reversal of cirrhosis or a significant reversal of vascular changes in conditions of established cirrhosis.es
dc.formatapplication/pdfes
dc.format.extent17es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/46331
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectLiver fibrosises
dc.subjectHepatic myofibroblastses
dc.subject.other616 - Patología. Medicina clínica. Oncologíaes
dc.titleLiver fibrosis: a dynamic and potentially reversible processes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.25, nº8 (2010)