Publication: Electron microscopic observations of elastic
fibres in the lung and aorta of tight-skin
and beta-aminopropionitrile-fed mice
Authors
Masumi Akita ; Seong Ho Lee ; Katsuji Kaneko
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The lung of the tight-skin (TSK) mouse
was characterized by enlargement of the air spaces.
Elastin in the alveolar walls of the TSK mouse
exhibited fragmentation. The aorta of the TSK mouse
was characterized by marked hyperplasia of loose
connective tissue in the adventitia. Collagen fibres and
ruthenium red-positive materials were markedly
increased. Microfibrils surrounding elastin in the
adventitia of the aorta were not clear in the TSK
mouse.
In the lung of the beta-aminopropionitrile
(BAPN)-fed mouse. enlargement of the alveolar air
spaces was not prominent compared with the TSK
mouse. Elastic fibres in the alveolar walls did not show
the fragmentation observed in the TSK mouse, and
microfibrils surrounding elastin were clearly observed.
However. elastic laminae in the media of the BAPNfed
mouse aorta were swollen and fragmented. Elastic
fibres in the adventitia exhibited a normal appearance
and microfibrils surrounding elastin in the adventitia
were clearly observed.
The results suggest that the mechanism of the
connective tissue abnormality in the TSK mouse is
different from that of BAPN. which inhibits the
activity of lysyl oxidase. The abnormality of elastin
and microfibrils surrounding elastin in the TSK mouse
probably plays a role in the deformity or degradation
of elastic fibres and the structural changes of the lung.
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