Publication: INF-γ sensitizes head and neck squamous cell
carcinoma cells to chemotherapy-induced apoptosis
and necroptosis through up-regulation of Egr-1
Authors
Xu, Bei ; Shu, Yongqian ; Liu, Peng
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
https://doi.org/10.14670/HH-29.1437
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info:eu-repo/semantics/article
Description
Abstract
Head and neck squamous cell carcinoma
(HNSCC) is the sixth most common cancer worldwide.
Acquired resistance to standard chemotherapy accounts
for most of treatment failure. Here we demonstrate that
Interferon-γ (INF-γ) may up-regulate Egr-1 gene
expression in HNSCC cell line SCC-25. Forced
expression of Egr-1 sensitizes SCC-25 cells to
chemotherapy-induced apoptosis and necroptosis, a
novel form of programmed cell death. Egr-1 upregulation also significantly increases the production of
Thrombospondin-1 (TSP-1), a matricellular glycoprotein
which has been described to induce cell death in
HNSCC. Moreover, INF-γ-induced sensitization of cells
to chemotherapy-mediated cell death and TSP-1
production could be markedly abolished by Egr-1
silencing. The present investigation provides the first
evidence that INF-γ may sensitize HNSCC cells to
chemotherapy-induced apoptosis and necroptosis
through up-regulation of Egr-1. These data support the
combination use of INF-γ and cytotoxic drugs for
HNSCC Therapy.
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