Publication: Chronic carotid glomitis in heroin addiction
Authors
Porzionato, A. ; Macchi, Verónica ; Parenti, Anna ; De Caro, Raffaelle
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The aim of the present work was to
investigate the occurrence and immunological
characteristics of chronic carotid glomitis in opiate
addicts. Carotid bodies were sampled at autopsy from 50
subjects who died of heroin intoxication (mean age 28
years), and from 16 young (24 years) and 10 older
subjects (66 years) who died of trauma. Sections were
stained with haematoxylin-eosin and azan-Mallory, and
immunohistochemistry was carried out with anti-CD45,
-CD3, -CD8, -CD4, -CD20, -CD68, -CD56.
Inflammatory aggregates were not observed in young
cases, but were found in 21/50 (42%) opiate cases and in
4/10 (40%) older cases. Infiltrates were mainly located
in subcapsular and interlobular positions, and were also
found around nerve fibres. Inflammatory aggregates
were mainly composed of T suppressor/cytotoxic
lymphocytes (50-80%). Monocytic/macrophagic cells
and B lymphocytes comprised about 10% and 5-20% of
inflammatory cells, respectively. T helper lymphocytes
were fewer and only rare Natural Killer cells were
found. Chronic carotid glomitis must be included among
the autopsy findings of opiate addiction, and may be
ascribed to inflammatory reactions to exogenous
immunogens or to responses to drug-induced
degenerative changes of carotid body components.
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