Publication: Age-related degeneration of articular cartilage in the pathogenesis of osteoarthritis: molecular markers of senescent chondrocytes
Authors
Musumeci, Giuseppe ; Szychlinska, Marta Anna ; Mobasheri, Ali
item.page.secondaryauthor
item.page.director
Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
publication.page.editor
publication.page.department
DOI
https://doi.org/10.14670/HH-30.1
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Aging is a natural process by which every
single living organism approaches its twilight of
existence in a natural way. However, aging is also linked
to the pathogenesis of a number of complex diseases.
This is the case for osteoarthritis (OA), where age is
considered to be a major risk factor of this important and
increasingly common joint disorder. Half of the world's
population, aged 65 and older, suffers from OA.
Although the relationship between the development of
OA and aging has not yet been completely understood, it
is thought that age-related changes correlate with other
risk factors. The most prominent hypothesis linking
aging and OA is that chondrocytes undergo premature
aging due to several factors, such as excessive
mechanical load or oxidative stress, which induce the so
called “stress-induced senescent state”, which is
ultimately responsible for the onset of OA. This review
focuses on molecular markers and mechanisms
implicated in chondrocyte aging and the pathogenesis of
OA. We discuss the most important age-related
morphological and biological changes that affect
articular cartilage and chondrocytes. We also identify the
main senescence markers that may be used to recognize
molecular alterations in the extracellular matrix of
cartilage as related to senescence. Since the aging
process is strongly associated with the onset of osteoarthritis, we believe that strategies aimed at
preventing chondrocyte senescence, as well as the
identification of new increasingly sensitive senescent
markers, could have a positive impact on the
development of new therapies for this severe disease.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Este ítem está sujeto a una licencia Creative Commons. CC BY 4.0