Publication: ATG7 immunohistochemical expression in malignant pleural mesothelioma. A preliminary report
Authors
Rapisarda, Venerando ; Broggi, Giuseppe ; Caltabiano, Rosario ; Lombardo, Claudia ; Castorina, Sergio ; Trovato, Angela ; Ledda, Caterina ; Filetti, Veronica ; Loreto, Carla
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-396
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info:eu-repo/semantics/article
Description
Abstract
Literature evidence has demonstrated a high
incidence of asbestos-related malignant pleural
mesothelioma (MPM) in a Sicilian town (Biancavilla,
Italy), where fluoro-edenite (FE) fibers were discovered
some decades ago. As ATG7 immunohistochemical
analysis has been ascribed as a prognostic tool of
improved survival, we decided to investigate, in MPM
patients, exposed and not exposed to FE fibers, the
immunohistochemical expression of this autophagyrelated protein named ATG7. We analyzed the
correlation between ATG7 immunohistochemical level
and clinicopathological parameters. Twenty MPM tissue
samples, from patients with available clinical and
follow-up data, were included in paraffin and processed
for immunohistochemistry. The immunohistochemical
results confirmed activation of the autophagic process in
MPM. Densitometric and morphometric expressions of
ATG7 were significantly increased in MPMs when
compared to the control tissues. A significant association
of a high level of ATG7 with increased survival was
demonstrated, with a mean overall survival (OS) of 12.5
months for patients with high expression vs. a mean OS
of 4.5 months for patients with low ATG7 expression. In
addition, a significant correlation between ATG7
expression and the survival time of MPM patients was
observed. This study represents a starting point to
hypothesize the prognostic role of ATG7 which could be
a reliable prognostic indicator in MPM
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Citation
Histology and Histopathology Vol. 36, nĀŗ12 (2021)
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Este Ćtem estĆ” sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/