Publication: Glucose transporter-1 expression and prognostic significance in pancreatic carcinogenesis
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Date
2009
Authors
Pizzi, Sara ; Porzionato, Andrea ; Pasquali, Claudio ; Guidolin, Diego ; Sperti, Cosino ; Fogar, Paola ; Macchi, Verónica ; De Caro, Raffaelle ; Pedrazzoli, Sergio ; Parenti, Anna
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The purposes of this study were to evaluate
the prognostic significance of Glut-1 expression in
patients with pancreatic ductal adenocarcinoma, and to
analyse its expression in pancreatic intraepithelial
neoplasias (PanIN) and non invasive intraductal
papillary mucinous neoplasms (IPMN). Glut-1
expression was studied by immunohistochemistry in 60
pancreatic ductal adenocarcinomas and scored on a 4-
point scale (1: <25%; 2: 25-50%; 3: 50-75%; 4: >75%).
Relationships between Glut-1 score, histological grade
and MIB-1 score were evaluated by the Spearman rank
correlation test. Significant correlations were found
between Glut-1 expression and histological grade
(P<0.001) and MIB-1 score (P<0.01). Significant
prognostic factors by univariate analysis were stage
(P<0.0001), histological grade (P<0.001) and Glut-1
expression (P<0.005). Independent prognostic factors
after multivariate analysis were stage (P<0.001) and
Glut-1 expression (P<0.05), stratified as <50% and
>50%. The correlation of Glut-1 score with histological
grade and MIB-1 score indicated a higher glucose uptake
in poorly differentiated and highly proliferative
pancreatic cancer cells. Glut-1 immunohistochemical
expression provides a useful prognostic factor in
pancreatic ductal adenocarcinoma. Glut-1 expression
was not found in PanINs 1 but in 27.8% and 43.8% of
PanINs 2 and 3, and was not found in IPMNs with lowand
moderate-grade dysplasia but in 60% of IPMNs with
high-grade dysplasia, indicating Glut-1 involvement in a
relatively early phase of pancreatic carcinogenesis.
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