Publication: The biological role of Treg cells in
ectopic endometrium homeostasis
Authors
Basta, Pawel ; Koper, Krzysztof ; Kazmierczak, Wojciech ; Wisniewski, Michal ; Makarewicz, Adrianna ; Dutsch-Wicherek, Magdalena ; Kojs, Zbigniew ; Popiela, Tadeusz J. ; Slusarz, Robert ; Dubiel, Mariusz ; Wicherek, Lukasz
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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Description
Abstract
Although retrograde menstruation is
observed in up to 90% of women, endometriosis actually
develops in only15% of women. There is considerable
evidence in the literature that ectopic endometrial cells
are able to evade immune surveillance and that the
immune response in the microenvironment of ectopic
lesions is limited. Endometriosis develops when a
deficiency in the local immune response has been
generated, and progression of the disease is related to the
intensity of this process.
Over the last couple of decades it has been well
known that T regulatory lymphocytes (Tregs) play a
crucial role in controlling a variety of physiological and
pathological immune responses. In this review we have
focused on the physiological alteration of Treg cell
infiltration into the endometrium during the reproductive
processes of women. We discuss how a disturbance in
Treg cell expansion is involved in generating such
pathological processes as miscarriage and ectopic
pregnancy development. We hypothesize about the role
Treg cells might play in the survival of endometriosis
foci in ectopic localization and in the evasion of such
lesions from host immune surveillance.
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