Publication: Duodenal endocrine cells in mice with particular regard to age-induced changes
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Date
2000
Authors
Sandstrom, O. ; El-Salhy, M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Duodenal endocrine cell types in four age
groups of NMRI mice (1, 3, 12 and 24 months old) were
identified by immunocytochemistry and quantified by
computerized image analysis. Whereas the number of
secretin-immunoreactive cells was significantly
increased in the 24-month-old group, the number of
GIP-immunoreactive cells was reduced in 12-month-old
compared with 3-month-old mice. The number of
somatostatin-immunoreactive cells was fewer in both the
12- and 24-month-olds vis-a-vis the 3-month-old mice.
Whereas serotonin-immunoreactive cells were fewer in
both 1-month-old and 12-month-old mice, they were
more numerous in 24-month-old mice then in the 3-
month-old ones. The number of gastrin/CCK-immunoreactive
cells was unaffected by age. The cell secretory
index (CSI) of secretin- and serotonin-immunoreactive
cells was increased in the 24-month-old mice vis-a-vis
the 3-month-old ones and the CSI of GIP- and
somatostatin-immunoreactive cells was increased in 12-
month-old mice vis-a-vis 3-month-old rnice. In contrast,
the CSI of somatostatin- and serotonin-immunoreactive
cells in 1-month-old mice was lower than that of 3-
month-old-mice. The nuclear volume of secretin-, GIP-,
gastrin/CCK- and serotonin-immunoreactive cells was
less in 1-month-olds than in 3-month-old mice. Whereas
the nuclear volume of somatostatin-immunoreactive
cells was decreased in 12-month-old animals, that of
gastrin/CCK- and serotonin-immunoreactive cells was
greater in 24-month-old mice than in 3-month-old ones.
It is concluded that these changes may be secondary to
structural and functional changes in the gastrointestinal
tract caused by ageing. It is possible that these changes
are involved in the development of dysfunction of the
gut observed at advanced age.
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