Publication: Changes in vascular extracellular matrix composition during decidual spiral arteriole remodeling in early human pregnancy
Authors
Smith, Samantha D. ; Choudhury, Ruhul H. ; Matos, Patricia ; Horn, James A. ; Lye, Stephen J. ; Dunk, Caroline E. ; Aplin, John D. ; Jones, Rebecca L. ; Harris, Lynda K
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
DOI: 10.14670/ HH-11-696
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info:eu-repo/semantics/article
Description
Abstract
Uterine spiral arteriole (SA) remodeling in
early pregnancy involves a coordinated series of events
including decidual immune cell recruitment, vascular
cell disruption and loss, and colonization by placentalderived extravillous trophoblast (EVT). During this
process, decidual SA are converted from narrow,
muscular vessels into dilated channels lacking
vasomotor control. We hypothesized that this extensive
alteration in SA architecture must require significant
reorganization and/or breakdown of the vascular
extracellular matrix (ECM). First trimester decidua
basalis (30 specimens) was immunostained to identify
spiral arterioles undergoing trophoblast-independent and
-dependent phases of remodeling. Serial sections were
then immunostained for a panel of ECM markers, to
examine changes in vascular ECM during the
remodeling process. The initial stages of SA remodeling
were characterized by loss of laminin, elastin, fibrillin,
collagen types III, IV and VI from the basement
membrane, vascular media and/or adventitia, and
surrounding decidual stromal cells. Loss of ECM
correlated with disruption and disorganization of
vascular smooth muscle cells, and the majority of
changes occurred prior to extensive colonization of the
vessel wall by EVT. The final stages of SA remodeling,
characterized by the arrival of EVT, were associated
with the increased mural deposition of fibronectin and
fibrinoid. This study provides the first detailed analysis
of the spatial and temporal loss of ECM from the walls
of remodeling decidual SA in early pregnancy.
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