Publication: Further characterization of spontaneous arthritic changes in murine squamo-mandibular joint: histopathological aspects
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Date
1986
Authors
Livne, E. ; Silbermann, M.
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Publisher
Murcia : F. Hernández
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Description
Abstract
The appearance of age-related ulcerative
changes in the mouse mandibular condyle were evaluated
by light and electron microscopy examinations. Fibrillations
appeared along the articular surface and in deeper
tissue regions, as early as at six months of age. Such
changes were characterized by a marked loss of the tissue's
cellularity and by a marked reduction in matrix metachromasia
and safranin-0 staining. These microscopical
changes were accompanied by a reduced reactivity for both
ruthenium red and colloidal iron binding, as noted
ultrastructurally. At the same time, increasing numbers
of erythrocytes appeared to be adhered to the surface
irregularities and were also found in deeper regions within
the articular lesions. Using morphological criteria, it
became apparent that the degenerative changes of aging
articular cartilage started at the more superficial regions
of the tissue and only thereafter proceeded toward the
chondro-osseous junction. Also, with the advancement of
age, the degenerative changes became more severe
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