Publication: Angiopoietin-1 is associated with a decreased risk of lymph node metastasis in early stage cervical cancer
Authors
Cai, E. ; Yang, Dongyun ; Zhang, Yifan ; Cai, Jing ; Sun, Si ; Yang, Ping ; Huang, Yuhui ; Han, Qing ; Xiong, Zhoufang ; Wang, Shaohai
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-234
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info:eu-repo/semantics/article
Description
Abstract
Objectives. Lymph node metastasis (LNM) is
an important determinant of prognosis in patients with
cervical cancer. Members of the angiopoietin family
have been demonstrated to regulate tumor-associated
angiogenesis and lymphangiogenesis. This study aimed
to investigate the expression levels of angiopoietin-1
(ANG1) and angiopoietin-2 (ANG2) in clinically early
stage of cervical cancer along with their correlations
with LNM.
Methods. In total, 124 human cervical cancer cases
classified into stage IA-IIB in accordance with the
International Federation of Gynecology and Obstetrics
(FIGO) 2009 staging criteria were included. ANG1 and
ANG2 expression levels in the tumor sections were
assessed by immunohistochemistry (IHC). Univariate
and multivariate logistic regression models, including
age at diagnosis, FIGO stage, tumor size, pathological
type, histological grading, depth of stromal invasion,
lymph-vascular space invasion (LVSI) and the
expression status of ANG1 and ANG2, were used to
evaluate the odds ratios (ORs) for LNM.
Results. ANG1 and ANG2 were positively
expressed in 75 (60.5%) and 89 (71.8%) cervical cancers
respectively, with predominant staining in the cytoplasm.
ANG1 expression was significantly decreased in tumors
with LNM, while no correlation was observed between
ANG2 expression and LNM. More importantly, the
multivariate logistic regression analysis demonstrated
that high ANG1 expression was an independent
protective factor of LNM (OR 0.107, 95% confidential
interval [CI] 0.020~0.567), while LVSI was an
independent risk factor of LNM (OR 34.313, 95% CI
5.914~199.092).
Conclusion. ANG1 is associated with a significantly
decreased risk of LNM in early stage cervical cancer.
The predictive value and role of ANG1 in LNM needs to
be further investigated in future studies.
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